• AboutOpen or Close

    Each Film coated tablet contains:
    Drotaverine Hydrochloride 80 mg.
    Aceclofenac IP 100 mg.
    Color: Sunset Yellow

  • IndicationsOpen or Close

    Smooth muscle spasm
    Gastrointestinal colic pain
    Renal colic pain
    Uterine neck spasm
    Post MTP(Medical termination of pregnancy)
    Post D&C(Dilatation and curettage)
    Post surgical spasm
    Irritable bowel syndrome

  • Mode Of ActionOpen or Close

    Mechanism of Action of Drotaverine

    Drotaverine has spasmolytic and vasodilating actions. It exerts its action by inhibiting phosphodiesterase enzyme IV. This will leads to a decrease in cyclic AMP level and reduction in calcium ions (Ca2+). The reduction of calcium ions will dilates the unstipped muscles and blood vessels strongly and relieves spasm of smooth muscles.

    Mechanism of Action of Aceclofenac

    This drug has several mechanism of action.
    1. It inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action).
    2. It blocks degeneration and stimulates synthesis of extra cellular matrix of cartilages by inhibiting the action of different cytokines.
    3. Drug and its metabolites inhibit IL-6 production by human chondrocytes. This leads to inhibition of increase of inflammatory cells in synovial tissue, inhibition of IL-1 amplification, inhibition of increased MMP synthesis and thus ensuring proteoglycan production.
    4. It inhibits IL-1 and TNF production by human chondrocytes, inflammatory cells and synovial cells and therefore blocks suppression of GAG and collagen synthesis and stimulates growth factors mediated synthesis of GAG and collagen.
    5. 4`-hydroxyaceclofenac a metabolite of aceclofenac inhibits pro MMP1 and pro MMP3 produced by synovial cells (Rheumatoid Synovial Cells) in serum and in synovial fluid and thus inhibits progressive joint destruction by MMPs.
    6. Aceclofenac inhibits Neutrophil Adhesion & Accumulation at the inflammatory site in the early phase and thus blocks the pro-inflammatory actions of Neutrophils.
    7. Aceclofenac is also an NSAID with greater COX-2 specificity

  • Contra-indicationsOpen or Close

    Hypersensitivity to the drug
    Bleeding from the stomach or intestines
    Moderate to severely decreased kidney function
    Hypersensitivity to other NSAIDs
    Active peptic ulcer

  • PharmacokinetsOpen or Close

    Pharmacokinets of Drotaverine

    Absorption: Drotaverine is rapidly absorbed after oral administration. Distribution: It is widely distributed in protein bound form. Metabolism: Extensively metabolised in the liver. Excretion: It is excreted mainly with the bile.

    Pharmacokinets of Aceclofenac

    Absorption- It is rapidly and completely absorbed after oral administration Distribution- Widely distributed in the body as protein-bound form. It is highly protein-bound (>99.7%). Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 60% of those in plasma. Metabolism- Metabolized into metabolites in the liver. Main metabolite is 4 hydroxyaceclofenac Excretion- It is excreted through urine mainly as conjugated hydroxymetabolites

  • Warning / PrecautionsOpen or Close

    The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Drotaverine - Aceclofenac is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.

  • DosagesOpen or Close

    The dosage of Drotaverine-Aceclofenac prescribed to each patient will vary. Always follow your physicians instructions and/or the directions on the prescription drug label.

    Missed Dose of Drotaverine-Aceclofenac

    If your physician has instructed or directed you to take Drotaverine-Aceclofenac medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.

    Overdose of Drotaverine-Aceclofenac

    Any medication taken in excess can have serious consequences. If you suspect an overdose of Drotaverine-Aceclofenac, seek medical attention immediately.

  • AvailibilityOpen or Close

    O my friend - but it is too much for my strength - I sink under the weight of the splendour of these visions!

    A wonderful serenity has taken possession of my entire soul, like these sweet mornings of spring which I enjoy with my whole heart.

  • PresentationOpen or Close
  • PricesOpen or Close
    10 Tablets
    75 INR
    100 Tablets
    600 INR
    Save 150 INR
    500 Tablets
    2500 INR
    Save 1250 INR
    1000 Tablets
    4000 INR
    Save 3500 INR
  • InquiryOpen or Close
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  • DistributorsOpen or Close
    Distributors Gujarat
    G M DISTRIBUTORS : +91 989 811 2101
    MEDIL HEALTHCARE : +91 79 26651108
    PAVAN’S MEDICARE : +91 2744 223124
    BRAHMANI MEDICAL AGENCY: +91 942 759 8489
    AMIZARA DISTRIBUTORS : +91 2742 257108
    ECHAR BIOTECH : +91 990 920 2904
    SAGAR DISTRIBUTORS : +91 972 772 5996
  • Contact UsOpen or Close

    5/B Mangaltrith Tower B Opp Dharnidhar Temple
    Vasna, Amedabad-380007
    Email : Info@aceverin.com
    Call : +91 9427421234

It should not be understood to indicate that the use of Aceverin - Aceclofenac is safe, appropriate or effective for all.